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Molecular Biology and Evolution, Vol 9, 678-687, Copyright © 1992 by Society for Molecular Biology and Evolution


ORIGINAL ARTICLE

Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases

K Tamura
Department of Biology, Tokyo Metropolitan University.

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C- content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.
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