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Molecular Biology and Evolution, Vol 9, 599-609, Copyright © 1992 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Maintenance of DQB1 polymorphisms in primates

LK Gaur, AL Hughes, ER Heise and J Gutknecht
Department of Microbiology and Immunology, Bowman Gray School of Medicine.

To understand the evolution of the class II major histocompatibility complex (MHC) DQB1 locus in primates, the second exons of seven DQB1 alleles from five non-human primate species were amplified by polymerase chain reaction. Comparisons of these and other primate sequences show that no between-species diversity is greater than within- species diversity, suggesting maintenance of DQB1 alleles through the history of Old-World primates. There is a preponderance of nonsynonymous nucleotide substitutions at antigen-binding-site codons; this pattern is in marked contrast to what is seen at the closely related, presumably nonfunctional DQB2 gene. The results support the hypothesis that DQB1 polymorphism is maintained by overdominant selection relating to antigen presentation.
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