Molecular Biology and Evolution, Vol 9, 587-598, Copyright © 1992 by Society for Molecular Biology and Evolution
G Pesole, E Sbisa, G Preparata and C Saccone
The origin of modern man is a highly debated issue that has recently been
tackled by using mitochondrial DNA sequences. The limited genetic
variability of human mtDNA has been explained in terms of a recent common
genetic ancestry, thus implying that all modern-population mtDNAs
originated from a single woman who lived in Africa less than 0.2 Mya. This
divergence time is based on both the estimation of the rate of mtDNA change
and its calibration date. Because different estimates of the rate of mtDNA
evolution can completely change the scenario of the origin of modern man,
we have reanalyzed the available mitochondrial sequence data by using an
improved version of the statistical model, the "Markov clock," devised in
our laboratory. Our analysis supports the African origin of modern man, but
we found that the ancestral female from which all extant human mtDNAs
originated lived in a time span of 0.3-0.8 Mya. Pushing back the date of
the deepest root of the human implies that the earliest divergence would
have been in the Homo erectus population.
ORIGINAL ARTICLE
The evolution of the mitochondrial D-loop region and the origin of modern man
Dipartimento di Biochimica e Biologia Molecolare, Universita di Bari, Italy.
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