Molecular Biology and Evolution, Vol 9, 381-393, Copyright © 1992 by Society for Molecular Biology and Evolution
AL Hughes
DNA sequences of alleles at the merozoite surface antigen-1 (MSA-1) gene
locus of the malaria parasite Plasmodium falciparum show evidence of
repeated past recombination events between alleles. These include both (1)
nonreciprocal recombination events that have homogenized certain gene
regions among alleles and (2) reciprocal recombination events that have
combined allelic segments with divergent evolutionary histories, thereby
enhancing allelic diversity. In three different gene regions, the rate of
nonsynonymous nucleotide substitution significantly exceeds that of
synonymous nucleotide substitution, implying that positive Darwinian
selection has acted to diversify alleles at the amino acid level. The MSA-1
polymorphism seems to be quite ancient; the two major allelic types have
been maintained for approximately 35 Myr.
ORIGINAL ARTICLE
Positive selection and interallelic recombination at the merozoite surface antigen-1 (MSA-1) locus of Plasmodium falciparum
Department of Biology, Institute of Molecular Evolutionary Genetics, Pennsylvania State University.
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