Molecular Biology and Evolution, Vol 9, 193-203, Copyright © 1992 by Society for Molecular Biology and Evolution
S Seino, GI Bell and WH Li
The chimpanzee and African green monkey insulin genes have been cloned and
sequenced. These two sequences together with the previously reported
sequences for the human and owl monkey insulin genes provide additional
support for the hominoid-rate-slowdown hypothesis, i.e., a slower rate of
nucleotide substitution in humans and apes than in monkeys. When these
sequences and other primate sequences available for the relative-rate test
were considered together, the substitution rate in the Old World monkey
lineage was shown to be significantly higher than the rates in the human
and chimpanzee lineages. This was true regardless of whether the eta-globin
pseudogene was included in the analysis. Therefore, in contrast to the
claim by Easteal, the hominoid- rate-slowdown is not unique to the
eta-globin pseudogene but appears to be a rather general phenomenon. On
average, the substitution rate at silent sites is about 1.5 times higher in
the Old World monkey lineage than in the human and chimpanzee lineages.
ORIGINAL ARTICLE
Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys
Howard Hughes Medical Institute, Department of Medicine, University of Chicago.
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