Molecular Biology and Evolution, Vol 9, 70-84, Copyright © 1992 by Society for Molecular Biology and Evolution
LA Sadler and CF Brunk
The 29 species of the Tetrahymena pyriformis complex are morphologically
identical while being quite diverse at the molecular level. These species
are also diverse relative to other eukaryotes. Phylogenetic relationships
within the complex have been difficult to determine, because there are
groups of closely related species, as well as individual species, that are
highly divergent. We have sequenced portions of two highly conserved
histone genes and the more rapidly evolving intergenic region between them.
These sequences have been used to construct a phylogeny for the complex. A
comparison of the amino- terminal portion of the histone H4 proteins from
the species of the complex reveals a high degree of sequence diversity
relative to that of other organisms. In contrast, the amino-terminal
portions of the histone H3 proteins of the species in the complex are
identical to each other. We also find that the pattern of nucleotide
substitution in the intergenic region differs from that described for
higher eukaryotes.
ORIGINAL ARTICLE
Phylogenetic relationships and unusual diversity in histone H4 proteins within the Tetrahymena pyriformis complex
Department of Biology, University of California, Los Angeles 90024.
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