Molecular Biology and Evolution, Vol 9, 56-69, Copyright © 1992 by Society for Molecular Biology and Evolution
MA Riley, SR Kaplan and M Veuille
Sequential polyacrylamide electrophoresis has revealed 20 allozymes of
xanthine dehydrogenase (XDH) in Drosophila pseudoobscura. DNA sequence
determination of seven isolates of the Xdh locus that represent six
allozyme classes are presented here. Of the 5,456 sites examined, 180 are
polymorphic, with 27 polymorphisms occurring at nonsynonymous, or
replacement, sites. An average of nine amino acids differ between XDH
allozyme classes, with 85% of the polymorphic amino acids singly
represented. The level and pattern of variation observed at Xdh argue that
the effective population size of the species is quite large--i.e., on the
order of 2 x 10(6)--and that the populations sampled are quite ancient. In
addition, as judged by two statistical tests, the levels of nucleotide
polymorphism observed at Xdh are compatible with predictions from the
neutral theory of molecular evolution.
ORIGINAL ARTICLE
Nucleotide polymorphism at the xanthine dehydrogenase locus in Drosophila pseudoobscura
Museum of Comparative Zoology, Harvard University.
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