Molecular Biology and Evolution, Vol 8, 49-70, Copyright © 1991 by Society for Molecular Biology and Evolution
RG Rowan and JA Hunt
The sequence of 1.6 kb of DNA surrounding the alcohol dehydrogenase (Adh)
gene from five species of the Planitibia subgroup of the Hawaiian
picture-winged Drosophila, with estimated divergence times of 0.4-5.1 Myr,
has been determined. The gene trees which were found by using the sequence
divergence from different regions of the sequences are generally in accord
with the phylogeny proposed for these species when chromosomal inversions
and island of origin are used. One of the species (D. picticornis) appears
to be more distant from the other species in this group than they are from
a member of the Grimshawi group (D. affinidisjuncta) which is chromosomally
more distant. Two of the species (D. differens and D. plantibia) show
heterogeneity in the nucleotide changes in the Adh coding region,
heterogeneity which is interpreted to be due to a gene conversion or
recombination after hybridization between the two species. The minimal rate
of nucleotide substitution of synonymous nucleotides and of nontranscribed
nucleotides downstream from the coding region is estimated as 1.5 x 10(- 8)
and 1.1 x 10(-8) substitutions/nucleotide/year, respectively. This rate is
two to three times the maximal rate estimated for mammalian synonymous
substitutions.
ORIGINAL ARTICLE
Rates of DNA change and phylogeny from the DNA sequences of the alcohol dehydrogenase gene for five closely related species of Hawaiian Drosophila
Department of Genetics, University of Hawaii, Honolulu 96822.
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