Molecular Biology and Evolution, Vol 7, 377-394, Copyright © 1990 by Society for Molecular Biology and Evolution
M Lynch and TJ Crease
A technique is presented for the partitioning of nucleotide diversity into
within- and between-population components for the case in which multiple
populations have been surveyed for restriction-site variation. This allows
the estimation of an analogue of FST at the DNA level. Approximate
expressions are given for the variance of these estimates resulting from
nucleotide, individual, and population sampling. Application of the
technique to existing studies on mitochondrial DNA in several animal
species and on several nuclear genes in Drosophila indicates that the
standard errors of genetic diversity estimates are usually quite large.
Thus, comparative studies of nucleotide diversity need to be substantially
larger than the current standards. Normally, only a very small fraction of
the sampling variance is caused by sampling of individuals. Even when 20 or
so restriction enzymes are employed, nucleotide sampling is a major source
of error, and population sampling is often quite important. Generally, the
degree of population subdivision at the nucleotide level is comparable with
that at the haplotype level, but significant differences do arise as a
result of inequalities in the genetic distances between haplotypes.
ORIGINAL ARTICLE
The analysis of population survey data on DNA sequence variation
Department of Biology, University of Oregon, Eugene 97403.
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