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Molecular Biology and Evolution, Vol 7, 293-302, Copyright © 1990 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

The involucrin genes of pig and dog: comparison of their segments of repeats with those of prosimians and higher primates

H Tseng and H Green
Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts 02115.

The involucrin genes of the dog and the pig have been cloned and sequenced. Like the corresponding genes of the prosimians, each contains a homologous segment of short tandem repeats at the same position in the coding region. However, the codon sequence of the repeats in the prosimians differs significantly from that of the nonprimate mammals. This evolution has been brought about by a combination of genetic modifications (selective deletions, mutations, and gene conversions). In the anthropoids, this segment of repeats was replaced by a modern one differing in location, sequence, and repeat length. In several of its properties the modern segment has continued the prosimian trend away from the nonprimates. The overall direction of the evolution of this segment has therefore been maintained even though there have been sudden changes in the evolutionary processes acting on the gene.
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