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Molecular Biology and Evolution, Vol 6, 669-684, Copyright © 1989 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

A tree reconstruction method that is economical in the number of pairwise comparisons used

J Hein
NIEHS, Research Triangle Park, North Carolina 27709.

A fast method for reconstructing phylogenies from distance data is presented. The method is economical in the number of pairwise comparisons needed. It can be combined with a new phylogenetic alignment procedure to yield an algorithm that gives a complete history of a set of homologous sequences. The method is applicable to very large distance matrices. An auxiliary program was developed that simplifies large phylogenies without ignoring biologically essential features. A set of 213 globins from vertebrates, plants, and Vitreoscilla (a prokaryote) were analyzed using this method.
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