Molecular Biology and Evolution, Vol 4, 406-425, Copyright © 1987 by Society for Molecular Biology and Evolution
N Saitou and M Nei
A new method called the neighbor-joining method is proposed for
reconstructing phylogenetic trees from evolutionary distance data. The
principle of this method is to find pairs of operational taxonomic units
(OTUs [= neighbors]) that minimize the total branch length at each stage of
clustering of OTUs starting with a starlike tree. The branch lengths as
well as the topology of a parsimonious tree can quickly be obtained by
using this method. Using computer simulation, we studied the efficiency of
this method in obtaining the correct unrooted tree in comparison with that
of five other tree-making methods: the unweighted pair group method of
analysis, Farris's method, Sattath and Tversky's method, Li's method, and
Tateno et al.'s modified Farris method. The new, neighbor-joining method
and Sattath and Tversky's method are shown to be generally better than the
other methods.
ORIGINAL ARTICLE
The neighbor-joining method: a new method for reconstructing phylogenetic trees
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225.
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