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Molecular Biology and Evolution, Vol 4, 46-55, Copyright © 1987 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Heteroplasmy in mice with deletion of a large coding region of mitochondrial DNA

P Boursot, H Yonekawa and F Bonhomme
Institut des Sciences de l'Evolution, Montpellier, France.

Polymorphism of animal mitochondrial DNA (mtDNA) has been shown to involve point mutations and limited length variations affecting essentially noncoding regions. In two wild mice of the European subspecies Mus mus musculus we found a mitochondrial mutant with a very large deletion in a coding region. The deletion is 5 kbp long (31% of the mitochondrial chromosome) and encompasses six tRNA genes and seven protein genes. The two mice were heteroplasmic: they contained a mixture of normal mtDNA and the deletion mutant. Although the latter is functionally defective, it represents 78%-79% of the mtDNA molecules in our preparations from each animal.
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 J. Biol. Chem.Home page
S. M. Tanhauser and P. J. Laipis
Multiple Deletions Are Detectable in Mitochondrial DNA of Aging Mice
J. Biol. Chem., October 20, 1995; 270(42): 24769 - 24775.
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