Molecular Biology and Evolution, Vol 4, 19-29, Copyright © 1987 by Society for Molecular Biology and Evolution
V Slagel, E Flemington, V Traina-Dorge, H Bradshaw and P Deininger
Thirteen and 10 sequences of the Alu family of repeated DNA elements found
within the human thymidine kinase and beta-tubulin genes, respectively,
were compared. These genes have approximately five times the expected
density of Alu family members. The consensus sequence that could be drawn
from these 23 Alu family members would differ slightly from others drawn
from random Alu family sequences but only at very heterogeneous positions.
The different Alu family members do show different pairwise percentage
identities, with approximately 15% (7 of 48 Alu family members analyzed) of
them clearly representing a separate subfamily of sequences. This analysis
also confirms the species- specific differences between human and the
prosimian Galago crassicaudatus Alu family members. These data are
consistent with both the origin of these sequences in primates less than
65-70 Myr ago and amplification since that time to their present 500,000
copies. The data do not show any special relationships among densely
clustered Alu family members.
ORIGINAL ARTICLE
Clustering and subfamily relationships of the Alu family in the human genome
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112.
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