Molecular Biology and Evolution, Vol 3, 322-329, Copyright © 1986 by Society for Molecular Biology and Evolution
M Bulmer
Substitution rates in pseudogenes can be used to estimate the frequencies
of different types of mutation on the assumption that pseudogenes are not
subject to selective constraints. These rates are used here to investigate
the effect of neighboring bases on mutation rates. There is a marked
increase in the frequency of transitions, though not of transversions, from
the doublet CG. There are also some smaller effects of neighboring bases on
the frequencies of transitions from adenine and thymine. The results are
used to predict dinucleotide frequencies in a stretch of DNA subject to no
selective constraints and to investigate the possibility of non-randomness
in the usage of stop codons.
ORIGINAL ARTICLE
Neighboring base effects on substitution rates in pseudogenes
Department of Biomathematics, University of Oxford, England.
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