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Molecular Biology and Evolution, Vol 3, 179-190, Copyright © 1986 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Long interspersed L1 repeats in rabbit DNA are homologous to L1 repeats of rodents and primates in an open-reading-frame region

GW Demers, K Brech and RC Hardison
Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.

Determination of the DNA sequence of a cluster of repetitive elements located 3' to the rabbit beta-1 globin gene shows that previously identified B, E, and D repeats are linked to form a long repeat. The B and E regions are homologous to the L1 long interspersed repeats of primates and rodents. Thus L1 repeats are widely dispersed in several different mammalian orders. The sequence similarity among L1 repeats from three species is limited to a long segment that contains extensive open reading frames. This conserved region is followed by a highly divergent segment that corresponds to a 3' untranslated region. The conservation of sequences in the open-reading-frame region coupled with the divergence of the untranslated region supports the hypothesis that the L1 repeats are derived from transcripts of a functional gene that encodes a protein.
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Home page
 Cold Spring Harb Symp Quant BiolHome page
J. Skowronski and M.F. Singer
The Abundant LINE-1 Family of Repeated DNA Sequences in Mammals: Genes and Pseudogenes
Cold Spring Harb Symp Quant Biol, January 1, 1986; 51(0): 457 - 464.
[Abstract] [PDF]


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