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MBE Advance Access originally published online on March 19, 2009
Molecular Biology and Evolution 2009 26(6):1195-1198; doi:10.1093/molbev/msp053
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© The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Lowly Expressed Human MicroRNA Genes Evolve Rapidly

Han Liang* and Wen-Hsiung Li*,{dagger}

* Department of Ecology and Evolution, University of Chicago
{dagger} Biodiversity Research Center, Academia Sinica, Taipei, Taiwan 115

E-mail: whli{at}uchicago.edu.

Accepted for publication March 10, 2009.

To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that ~30% of currently annotated human miRNA genes are almost free of selective pressure.

Key Words: microRNA expression • sequence divergence • spatial clustering • selective pressure

Takashi Gojobori, Associate Editor


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