MBE Advance Access originally published online on January 4, 2008
Molecular Biology and Evolution 2008 25(3):591-602; doi:10.1093/molbev/msn004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Research Articles |
Rapid Rates of Lineage-Specific Gene Duplication and Deletion in the
-Globin Gene Family
School of Biological Sciences, University of Nebraska
E-mail: jstorz2{at}unl.edu.
Accepted for publication January 1, 2008.
Phylogeny reconstructions of the globin gene families have revealed that paralogous genes within species are often more similar to one another than they are to their orthologous counterparts in closely related species. This pattern has been previously attributed to mechanisms of concerted evolution such as interparalog gene conversion that homogenize sequence variation between tandemly duplicated genes and therefore create the appearance of recent common ancestry. Here we report a comparative genomic analysis of the
-globin gene family in mammals that reveal a surprisingly high rate of lineage-specific gene duplication and deletion via unequal crossing-over. Results of our analysis reveal that patterns of sequence similarity between paralogous
-like globin genes from the same species are only partly explained by concerted evolution between preexisting gene duplicates. In a number of cases, sequence similarity between paralogous sequences from the same species is attributable to recent ancestry between the products of de novo gene duplications. As a result of this surprisingly rapid rate of gene gain and loss, many mammals possess
-like globin genes that have no orthologous counterparts in closely related species. The resultant variation in gene copy number among species may represent an important source of regulatory variation that affects physiologically important aspects of blood oxygen transport and aerobic energy metabolism.
Key Words: birth-and-death evolution concerted evolution gene duplication gene family
-globin hemoglobin
1 Present address: Instituto de Ecologia y Evolucion, Universidad Austral de Chile, Valdivia, Chile.
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
A. M. Runck, H. Moriyama, and J. F. Storz Evolution of Duplicated {beta}-Globin Genes and the Structural Basis of Hemoglobin Isoform Differentiation in Mus Mol. Biol. Evol., November 1, 2009; 26(11): 2521 - 2532. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. F. Storz, A. M. Runck, S. J. Sabatino, J. K. Kelly, N. Ferrand, H. Moriyama, R. E. Weber, and A. Fago Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin PNAS, August 25, 2009; 106(34): 14450 - 14455. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Opazo, A. M. Sloan, K. L. Campbell, and J. F. Storz Origin and Ascendancy of a Chimeric Fusion Gene: The {beta}/{delta}-Globin Gene of Paenungulate Mammals Mol. Biol. Evol., July 1, 2009; 26(7): 1469 - 1478. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. L. McGrath, C. Casola, and M. W. Hahn Minimal Effect of Ectopic Gene Conversion Among Recent Duplicates in Four Mammalian Genomes Genetics, June 1, 2009; 182(2): 615 - 622. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. G. Hoffmann, J. C. Opazo, and J. F. Storz New Genes Originated via Multiple Recombinational Pathways in the {beta}-Globin Gene Family of Rodents Mol. Biol. Evol., December 1, 2008; 25(12): 2589 - 2600. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Opazo, F. G. Hoffmann, and J. F. Storz Differential loss of embryonic globin genes during the radiation of placental mammals PNAS, September 2, 2008; 105(35): 12950 - 12955. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. F. Storz, F. G. Hoffmann, J. C. Opazo, and H. Moriyama Adaptive Functional Divergence Among Triplicated {alpha}-Globin Genes in Rodents Genetics, March 1, 2008; 178(3): 1623 - 1638. [Abstract] [Full Text] [PDF] |
||||


