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MBE Advance Access originally published online on December 10, 2007
Molecular Biology and Evolution 2008 25(2):409-416; doi:10.1093/molbev/msm269
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Selective Sweeps in a 2-Locus Model for Sex-Ratio Meiotic Drive in Drosophila simulans

Nicolas Derome*,{dagger},{ddagger},1, Emmanuelle Baudry§, David Ogereau{dagger},{ddagger}, Michel Veuille* and Catherine Montchamp-Moreau{dagger},{ddagger}

* Ecole Pratique des Hautes Etudes, Paris, France
{dagger} Laboratoire Evolution Génome et Spéciation, UPR9034, CNRS 91198 Gif-sur Yvette Cedex, France
{ddagger} Département de biologie Université Paris-Sud 11, 91405 Orsay Cedex, France Gif-sur-Yvette, France
§ Ecologie, Systématique et Evolution, CNRS UMR8079, Université Paris-Sud 11, 91405 Orsay, France

E-mail: veuille{at}mnhn.fr.

Accepted for publication November 1, 2007.

A way to identify loci subject to positive selection is to detect the signature of selective sweeps in given chromosomal regions. It is revealed by the departure of DNA polymorphism patterns from the neutral equilibrium predicted by coalescent theory. We surveyed DNA sequence variation in a region formerly identified as causing "sex-ratio" meiotic drive in Drosophila simulans. We found evidence that this system evolved by positive selection at 2 neighboring loci, which thus appear to be required simultaneously for meiotic drive to occur. The 2 regions are approximately 150-kb distant, corresponding to a genetic distance of 0.1 cM. The presumably large transmission advantage of chromosomes carrying meiotic drive alleles at both loci has not erased the individual signature of selection at each locus. This chromosome fragment combines a high level of linkage disequilibrium between the 2 critical regions with a high recombination rate. As a result, 2 characteristic traits of selective sweeps—the reduction of variation and the departure from selective neutrality in haplotype tests—show a bimodal pattern. Linkage disequilibrium level indicates that, in the natural population from Madagascar used in this study, the selective sweep may be as recent as 100 years.

Key Words: meiotic drive • sex ratio • selective sweep • Drosophila simulans

1 Present address: Université Laval, Québec, Canada.

Jody Hey, Associate Editor


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