MBE Advance Access originally published online on September 26, 2008
Molecular Biology and Evolution 2008 25(12):2699-2707; doi:10.1093/molbev/msn214
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Research Articles |
An Ancient Evolutionary Origin of Genes Associated with Human Genetic Diseases
o*,
* Max-Planck Institut für Evolutionsbiologie, August-Thienemannstrasse 2, Plön, Germany
Laboratory of Evolutionary Genetics, Division of Molecular Biology, Ru
er Bokovi
Institute, Bijeni
ka cesta 54, Zagreb, Croatia
E-mail: tautz{at}evolbio.mpg.de.
Accepted for publication September 19, 2008.
Several thousand genes in the human genome have been linked to a heritable genetic disease. The majority of these appear to be nonessential genes (i.e., are not embryonically lethal when inactivated), and one could therefore speculate that they are late additions in the evolutionary lineage toward humans. Contrary to this expectation, we find that they are in fact significantly overrepresented among the genes that have emerged during the early evolution of the metazoa. Using a phylostratigraphic approach, we have studied the evolutionary emergence of such genes at 19 phylogenetic levels. The majority of disease genes was already present in the eukaryotic ancestor, and the second largest number has arisen around the time of evolution of multicellularity. Conversely, genes specific to the mammalian lineage are highly underrepresented. Hence, genes involved in genetic diseases are not simply a random subset of all genes in the genome but are biased toward ancient genes.
Key Words: phylostratigraphy • orphan genes
Sudhir Kumar, Associate Editor
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