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MBE Advance Access originally published online on March 25, 2007
Molecular Biology and Evolution 2007 24(6):1283-1285; doi:10.1093/molbev/msm061
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© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Assessing the Conservation of Mammalian Gene Expression Using High-Density Exon Arrays

Yi Xing*,{dagger}, Zhengqing Ouyang{ddagger}, Karen Kapur{dagger}, Matthew P. Scott§,||,¶,# and Wing Hung Wong{dagger}

* Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa
{dagger} Department of Statistics, Stanford University
{ddagger} Department of Biological Sciences, Stanford University
§ Department of Developmental Biology, Stanford University School of Medicine
|| Department of Genetics, Stanford University School of Medicine
Department of Bioengineering, Stanford University School of Medicine
# Howard Hughes Medical Institute, Chevy Chase, Maryland

E-mails: yi-xing{at}uiowa.edu; whwong{at}stanford.edu.

Accepted for publication March 19, 2007.

Microarray data from multiple species have been used to study evolutionary constraints on gene expression. Expression measurements from conventional microarray platforms such as the 3' expression arrays are strongly affected by platform-dependent probe effects that may introduce apparent but misleading discrepancies between species. In this manuscript, we assess the conservation of mammalian gene expression in adult tissues using data from a high-density exon array platform. The exon arrays have more than 6 million probes on a single array targeting all exons in a genome. We find that, unlike 3' array data, gene expression measurements from exon arrays reveal patterns of gene expression that are highly conserved between humans and mice in multiple tissues. Our analysis provides strong evidence for widespread stabilizing selection pressure on transcript abundance during mammalian evolution.

Key Words: evolution • gene expression • selection pressure • microarray • exon array

Kenneth Wolfe, Associate Editor


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