Skip Navigation


MBE Advance Access originally published online on January 11, 2007
Molecular Biology and Evolution 2007 24(3):868-874; doi:10.1093/molbev/msm004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
24/3/868    most recent
msm004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pereira, L.
Right arrow Articles by Macaulay, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pereira, L.
Right arrow Articles by Macaulay, V.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Luísa Pereira*,{dagger}, João Gonçalves{ddagger}, Ricardo Franco-Duarte*, Júlia Silva{ddagger}, Tiago Rocha§, Christiane Arnold§, Martin Richards|| and Vincent Macaulay

* Instituto de Patologia e Imunologia Molecular da Universidade do Porto, (IPATIMUP), Porto, Portugal
{dagger} Medical Faculty, University of Porto, Portugal
{ddagger} Centro de Genética Humana Instituto Nacional de Saude Dr Ricardo Jorge, Lisboa, Portugal
§ Maternidade Dr Alfredo da Costa, Lisboa, Portugal
|| Institute of Integrative & Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
Department of Statistics, University of Glasgow, Glasgow, United Kingdom

E-mail: lpereira{at}ipatimup.pt.

Accepted for publication January 3, 2007.

The first complete mitochondrial DNA (mtDNA) sequences (~16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

Key Words: mtDNA • complete sequences • asthenozoospermia • association

Connie Mulligan, Associate Editor


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
M. K. Fujita, J. L. Boore, and C. Moritz
Multiple Origins and Rapid Evolution of Duplicated Mitochondrial Genes in Parthenogenetic Geckos (Heteronotia binoei; Squamata, Gekkonidae)
Mol. Biol. Evol., December 1, 2007; 24(12): 2775 - 2786.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.