Skip Navigation


MBE Advance Access originally published online on June 29, 2006
Molecular Biology and Evolution 2006 23(9):1808-1816; doi:10.1093/molbev/msl049
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrowOA All Versions of this Article:
23/9/1808    most recent
msl049v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (63)
Google Scholar
Right arrow Articles by Brunet, F. G.
Right arrow Articles by Robinson-Rechavi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunet, F. G.
Right arrow Articles by Robinson-Rechavi, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 The Authors This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Research Article

Gene Loss and Evolutionary Rates Following Whole-Genome Duplication in Teleost Fishes

Frédéric G. Brunet*, Hugues Roest Crollius{dagger}, Mathilde Paris*, Jean-Marc Aury{ddagger}, Patricia Gibert§, Olivier Jaillon{ddagger}, Vincent Laudet* and Marc Robinson-Rechavi||

* Laboratoire de Biologie Moléculaire de la Cellule, INRA LA 1237, CNRS UMR5161, IFR 128 BioSciences Lyon-Gerland, Ecole Normale Supérieure de Lyon, Lyon, France; {dagger} Dyogen Group, CNRS UMR8541, Ecole Normale Supérieure, Paris, France; {ddagger} Structure et évolution des génomes, CNRS UMR8030, Genoscope, Evry, France; § Laboratoire de Biométrie et Biologie Evolutive, CNRS UMR5558, Université Claude Bernard Lyon 1, Villeurbanne, France; and || Department of Ecology and Evolution, Biophore, University of Lausanne, Lausanne, Switzerland

E-mail: marc.robinson-rechavi{at}unil.ch.

Teleost fishes provide the first unambiguous support for ancient whole-genome duplication in an animal lineage. Studies in yeast or plants have shown that the effects of such duplications can be mediated by a complex pattern of gene retention and changes in evolutionary pressure. To explore such patterns in fishes, we have determined by phylogenetic analysis the evolutionary origin of 675 Tetraodon duplicated genes assigned to chromosomes, using additional data from other species of actinopterygian fishes. The subset of genes, which was retained in double after the genome duplication, is enriched in development, signaling, behavior, and regulation functional categories. The evolutionary rate of duplicate fish genes appears to be determined by 3 forces: 1) fish proteins evolve faster than mammalian orthologs; 2) the genes kept in double after genome duplication represent the subset under strongest purifying selection; and 3) following duplication, there is an asymmetric acceleration of evolutionary rate in one of the paralogs. These results show that similar mechanisms are at work in fishes as in yeast or plants and provide a framework for future investigation of the consequences of duplication in fishes and other animals.

Key Words: genome duplication • gene loss • neofunctionalization • Gene Ontology • evolutionary rates • selection


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
A. L. Hufton, S. Mathia, H. Braun, U. Georgi, H. Lehrach, M. Vingron, A. J. Poustka, and G. Panopoulou
Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention
Genome Res., November 1, 2009; 19(11): 2036 - 2051.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
K. S. Kassahn, V. T. Dang, S. J. Wilkins, A. C. Perkins, and M. A. Ragan
Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates
Genome Res., August 1, 2009; 19(8): 1404 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
C.-L. Chen, H. Zhou, J.-Y. Liao, L.-H. Qu, and L. Amar
Genome-wide evolutionary analysis of the noncoding RNA genes and noncoding DNA of Paramecium tetraurelia
RNA, April 1, 2009; 15(4): 503 - 514.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Wang, A. P. Lee, R. Kodzius, S. Brenner, and B. Venkatesh
Large Number of Ultraconserved Elements Were Already Present in the Jawed Vertebrate Ancestor
Mol. Biol. Evol., March 1, 2009; 26(3): 487 - 490.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
K. J. V. Nordstrom, M. C. Lagerstrom, L. M. J. Waller, R. Fredriksson, and H. B. Schioth
The Secretin GPCRs Descended from the Family of Adhesion GPCRs
Mol. Biol. Evol., January 1, 2009; 26(1): 71 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. L. Hufton, D. Groth, M. Vingron, H. Lehrach, A. J. Poustka, and G. Panopoulou
Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement
Genome Res., October 1, 2008; 18(10): 1582 - 1591.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
R. A. Studer, S. Penel, L. Duret, and M. Robinson-Rechavi
Pervasive positive selection on duplicated and nonduplicated vertebrate protein coding genes
Genome Res., September 1, 2008; 18(9): 1393 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
E. H Stolte, A. F de Mazon, K. M Leon-Koosterziel, M. Jesiak, N. R Bury, A. Sturm, H. F J Savelkoul, B M L. V. van Kemenade, and G. Flik
Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio
J. Endocrinol., August 1, 2008; 198(2): 403 - 417.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Semon and K. H. Wolfe
Preferential subfunctionalization of slow-evolving genes after allopolyploidization in Xenopus laevis
PNAS, June 17, 2008; 105(24): 8333 - 8338.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
C. Hernandez-Sanchez, A. Mansilla, F. de Pablo, and R. Zardoya
Evolution of the Insulin Receptor Family and Receptor Isoform Expression in Vertebrates
Mol. Biol. Evol., June 1, 2008; 25(6): 1043 - 1053.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Alsop and M. M. Vijayan
Development of the corticosteroid stress axis and receptor expression in zebrafish
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R711 - R719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. E. Shmukler, J. S. Clark, A. Hsu, D. H. Vandorpe, A. K. Stewart, C. E. Kurschat, S.-K. Choe, Y. Zhou, J. Amigo, B. H. Paw, et al.
Zebrafish ae2.2 encodes a second slc4a2 anion exchanger
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R1081 - R1091.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. R. Scannell and K. H. Wolfe
A burst of protein sequence evolution and a prolonged period of asymmetric evolution follow gene duplication in yeast
Genome Res., January 1, 2008; 18(1): 137 - 147.
[Abstract] [Full Text] [PDF]

Home page
 Brief Funct Genomic ProteomicHome page
G. Spudich, X. M. Fernandez-Suarez, and E. Birney
Genome browsing with Ensembl: a practical overview
Brief Funct Genomic Proteomic, October 29, 2007; (2007) elm025v1.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. A. Flanagan, C.-C. Chen, M. Coetsee, S. Mamputha, K. E. Whitlock, N. Bredenkamp, L. Grosenick, R. D. Fernald, and N. Illing
Expression, Structure, Function, and Evolution of Gonadotropin-Releasing Hormone (GnRH) Receptors GnRH-R1SHS and GnRH-R2PEY in the Teleost, Astatotilapia burtoni
Endocrinology, October 1, 2007; 148(10): 5060 - 5071.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.