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MBE Advance Access originally published online on April 18, 2006
Molecular Biology and Evolution 2006 23(7):1348-1356; doi:10.1093/molbev/msk025
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

The Rate of Adaptive Evolution in Enteric Bacteria

Jane Charlesworth* and Adam Eyre-Walker*,{dagger}

* Centre for Study of Evolution, School of Life Sciences, University of Sussex, Brighton, United Kingdom; and {dagger} National Evolutionary Synthesis Center, Durham, USA

E-mail: a.c.eyre-walker{at}sussex.ac.uk.

Here we estimate the rate of adaptive substitution in a set of 410 genes that are present in 6 Escherichia coli and 6 Salmonella enterica genomes. We estimate that more than 50% of amino acid substitutions in this set of genes have been fixed by positive selection between the E. coli and S. enterica lineages. We also show that the proportion of adaptive substitutions is uncorrelated with the rate of amino acid substitution or gene function but that it may be correlated with levels of synonymous codon usage bias.

Key Words: adaptive evolution • enteric bacteria • McDonald-Kreitman test


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