Skip Navigation


MBE Advance Access originally published online on April 28, 2006
Molecular Biology and Evolution 2006 23(7):1341-1344; doi:10.1093/molbev/msl001
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
23/7/1341    most recent
msl001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Richards, T. A.
Right arrow Articles by van der Giezen, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richards, T. A.
Right arrow Articles by van der Giezen, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Evolution of the Isd11–IscS Complex Reveals a Single {alpha}-Proteobacterial Endosymbiosis for All Eukaryotes

Thomas A. Richards* and Mark van der Giezen{dagger}

* School of Biosciences, University of Exeter, Exeter, United Kingdom; and {dagger} School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom

E-mail: m.vandergiezen{at}qmul.ac.uk.

Giardia and Trichomonas are eukaryotes without standard mitochondria but contain mitochondrial-type {alpha}-proteobacterium–derived iron–sulfur cluster (ISC) assembly proteins, located to mitosomes in Giardia and hydrogenosomes in Trichomonas. Although these data suggest a single common endosymbiotic ancestry for mitochondria, mitosomes, and hydrogenosomes, separate origins are still being proposed. Here, we present a bioinformatic analysis of Isd11, a recently described essential component of the mitochondrial ISC assembly pathway. Isd11 is unique to eukaryotes but functions closely with the {alpha}-proteobacterium–derived cysteine desulfurase IscS. We demonstrate the presence of homologues of Isd11 in all 5 eukaryotic supergroups sampled, including hydrogenosomal and mitosomal lineages. The eukaryotic invention of Isd11 as a functional partner to IscS directly implies a single shared {alpha}-proteobacterial endosymbiotic ancestry for all eukaryotes. This pinpoints the {alpha}-proteobacterial endosymbiosis to before the last common ancestor of all eukaryotes without ambiguity.

Key Words: mitochondria • mitosome • hydrogenosome • iron–sulfur cluster • origin of the eukaryotic cell


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Z. Marelja, W. Stocklein, M. Nimtz, and S. Leimkuhler
A Novel Role for Human Nfs1 in the Cytoplasm: Nfs1 ACTS AS A SULFUR DONOR FOR MOCS3, A PROTEIN INVOLVED IN MOLYBDENUM COFACTOR BIOSYNTHESIS
J. Biol. Chem., September 12, 2008; 283(37): 25178 - 25185.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
Y. Shan, E. Napoli, and G. Cortopassi
Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones
Hum. Mol. Genet., April 15, 2007; 16(8): 929 - 941.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.