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MBE Advance Access originally published online on April 18, 2006
Molecular Biology and Evolution 2006 23(7):1339-1340; doi:10.1093/molbev/msk024
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

Evidence that Protein Length Expansion and Contraction Is Partly Due to Mutational Events in Premeiotic Cells

Suzanne Bowen and Alan E. Wheals

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

E-mail: bssaew{at}bath.ac.uk.

Studies on the rate of evolution of proteins typically concentrate on rates of change of orthologous amino acids rather than on changes in size (i.e., generation of nonorthologous domains). Recent work has focused attention on Ser/Thr-rich regions in yeast as these tend to undergo size changes rapidly, with size polymorphisms commonly being found, especially in proteins with cell-surface localization. The underlying mechanism generating the indels is presently unclear though, due to a lack of correlation with the location of meiotic double-strand breaks, it has, by exclusion, been conjectured to be replication slippage. Here we provide new evidence to support this possibility. Notably, we show that Ser/Thr-rich repeat regions are more generally associated with the location of Mre11p in premeiotic cells. This is to be expected if the repeats were produced by mutational events in mitotic cells possibly through replication slippage.

Key Words: replication slippage • Ser/Thr rich • polymorphisms • yeast


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