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MBE Advance Access originally published online on December 27, 2005
Molecular Biology and Evolution 2006 23(4):721-722; doi:10.1093/molbev/msj086
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

The Effect of Multifunctionality on the Rate of Evolution in Yeast

Marcel Salathé, Martin Ackermann and Sebastian Bonhoeffer

Institute of Integrative Biology, ETH Zürich, CH 8092 Zürich, Switzerland

E-mail: marcel.salathe{at}env.ethz.ch.

Multifunctional genes are expected to evolve at lower rates because mutations in such genes that improve one function might often have deleterious effects on other functions. Here we tested for an association between multifunctionality and evolutionary rates in genes of Saccharomyces cerevisiae, and we find a highly significant negative correlation between the number of biological processes in which a gene is involved in and its rate of evolution. However, the magnitude of this effect is small, and the results do not support the notion that multifunctionality limits a gene's rate of evolution.

Key Words: pleiotropy • dN/dS • evolutionary genomics • rate of evolution


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[Abstract] [Full Text] [PDF]


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