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MBE Advance Access originally published online on October 12, 2005
Molecular Biology and Evolution 2006 23(2):235-239; doi:10.1093/molbev/msj034
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

A Test of the Master Gene Hypothesis for Interspersed Repetitive DNA Sequences

Louise J. Johnson and John F. Y. Brookfield

Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom

E-mail: john.brookfield{at}nottingham.ac.uk.

Many families of interspersed repetitive DNA elements, including human Alu and LINE (Long Interspersed Element) elements, have been proposed to have accumulated through repeated copying from a single source locus: the "master gene." The extent to which a master gene model is applicable has implications for the origin, evolution, and function of such sequences. One repetitive element family for which a convincing case for a master gene has been made is the rodent ID (identifier) elements. Here we devise a new test of the master gene model and use it to show that mouse ID element sequences are not compatible with a strict master gene model. We suggest that a single master gene is rarely, if ever, likely to be responsible for the accumulation of any repeat family.

Key Words: SINE • repetitive DNA • master gene • ID element • BC1


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