Skip Navigation


MBE Advance Access originally published online on September 6, 2006
Molecular Biology and Evolution 2006 23(12):2361-2369; doi:10.1093/molbev/msl108
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
23/12/2361    most recent
msl108v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Choulet, F.
Right arrow Articles by Leblond, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Choulet, F.
Right arrow Articles by Leblond, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Articles

Evolution of the Terminal Regions of the Streptomyces Linear Chromosome

Frédéric Choulet*, Bertrand Aigle*, Alexandre Gallois*, Sophie Mangenot{dagger}, Claude Gerbaud{ddagger}, Chantal Truong{dagger}, François-Xavier Francou{ddagger}, Céline Fourrier*, Michel Guérineau{ddagger}, Bernard Decaris*, Valérie Barbe{dagger}, Jean-Luc Pernodet{ddagger} and Pierre Leblond*

* Laboratoire de Génétique et Microbiologie, UMR INRA 1128, IFR 110, Université Henri Poincaré Nancy 1, Faculté des Sciences et Techniques, Vandoeuvre-lès-Nancy, France
{dagger} Génoscope, Centre National de Séquençage, Evry, France
{ddagger} Institut de Génétique et Microbiologie, UMR CNRS 8621, Université Paris-Sud 11, Orsay, France

E-mail: leblond{at}nancy.inra.fr.

Comparative analysis of the Streptomyces chromosome sequences, between Streptomyces coelicolor, Streptomyces avermitilis, and Streptomyces ambofaciens ATCC23877 (whose partial sequence is released in this study), revealed a highly compartmentalized genetic organization of their genome. Indeed, despite the presence of specific genomic islands, the central part of the chromosome appears highly syntenic. In contrast, the chromosome of each species exhibits large species-specific terminal regions (from 753 to 1,393 kb), even when considering closely related species (S. ambofaciens and S. coelicolor). Interestingly, the size of the central conserved region between species decreases as the phylogenetic distance between them increases, whereas the specific terminal fraction reciprocally increases in size. Between highly syntenic central regions and species-specific chromosomal parts, there is a notable degeneration of synteny due to frequent insertions/deletions. This reveals a massive and constant genomic flux (from lateral gene transfer and DNA rearrangements) affecting the terminal contingency regions. We speculate that a gradient of recombination rate (i.e., insertion/deletion events) toward the extremities is the force driving the exclusion of essential genes from the terminal regions (i.e., chromosome compartmentalization) and generating a fast gene turnover for strong adaptation capabilities.

Key Words: comparative genomics • linear bacterial chromosome • lateral gene transfer • contingency regions • Streptomyces


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Komatsu, T. Uchiyama, S. Omura, D. E. Cane, and H. Ikeda
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
PNAS, February 9, 2010; 107(6): 2646 - 2651.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
Y. Ohnishi, J. Ishikawa, H. Hara, H. Suzuki, M. Ikenoya, H. Ikeda, A. Yamashita, M. Hattori, and S. Horinouchi
Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350
J. Bacteriol., June 1, 2008; 190(11): 4050 - 4060.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Komatsu, M. Tsuda, S. Omura, H. Oikawa, and H. Ikeda
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol
PNAS, May 27, 2008; 105(21): 7422 - 7427.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
R. Bunet, M. V. Mendes, N. Rouhier, X. Pang, L. Hotel, P. Leblond, and B. Aigle
Regulation of the Synthesis of the Angucyclinone Antibiotic Alpomycin in Streptomyces ambofaciens by the Autoregulator Receptor AlpZ and Its Specific Ligand
J. Bacteriol., May 1, 2008; 190(9): 3293 - 3305.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. R. Marri, L. K. Harris, K. Houmiel, S. C. Slater, and H. Ochman
The Effect of Chromosome Geometry on Genetic Diversity
Genetics, May 1, 2008; 179(1): 511 - 516.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
F. Karray, E. Darbon, N. Oestreicher, H. Dominguez, K. Tuphile, J. Gagnat, M.-H. Blondelet-Rouault, C. Gerbaud, and J.-L. Pernodet
Organization of the biosynthetic gene cluster for the macrolide antibiotic spiramycin in Streptomyces ambofaciens
Microbiology, December 1, 2007; 153(12): 4111 - 4122.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
M. Ventura, C. Canchaya, A. Tauch, G. Chandra, G. F. Fitzgerald, K. F. Chater, and D. van Sinderen
Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum
Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 495 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. W. Udwary, L. Zeigler, R. N. Asolkar, V. Singan, A. Lapidus, W. Fenical, P. R. Jensen, and B. S. Moore
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
PNAS, June 19, 2007; 104(25): 10376 - 10381.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.