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MBE Advance Access originally published online on August 4, 2006
Molecular Biology and Evolution 2006 23(11):1995-1996; doi:10.1093/molbev/msl078
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Letter

The Hidden Value of Missing Genotypes

William Amos

Department of Zoology, Downing Street, Cambridge, UK

E-mail: wa100{at}hermes.cam.ac.uk.

Robotic systems allow vast genetic data sets to be generated automatically with little manual input, raising questions about accuracy. To test whether errors occur randomly, I used the frequencies of missing genotypes in a large human data set to construct a population tree. Remarkably, the gaps appear to carry as strong a phylogenetic signal as the actual data themselves.

Key Words: human population • microsatellite • null alleles • genetic distance • genotyping error


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