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MBE Advance Access originally published online on July 25, 2006
Molecular Biology and Evolution 2006 23(10):1869-1878; doi:10.1093/molbev/msl069
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Research Article

Evidence of Gene Conversion Associated with a Selective Sweep in Drosophila melanogaster

Sascha Glinka, David De Lorenzo and Wolfgang Stephan

Section of Evolutionary Biology, Department of Biology II, Ludwig-Maximilians University, Planegg-Martinsried, Germany

E-mail: glinka{at}zi.biologie.uni-muenchen.de.

Since Drosophila melanogaster colonized Europe from tropical Africa 10 to 15 thousand years ago, it is expected that adaptation has played a major role in this species in recent times. A previously conducted multilocus scan of noncoding DNA sequences on the X chromosome in an ancestral and a derived population of D. melanogaster revealed that some loci have been affected by directional selection in the European population. We investigated if the pattern of DNA sequence polymorphism in a region surrounding one of these loci can be explained by a hitchhiking event. We found strong evidence that the studied region around the gene unc-119 was shaped by a recent selective sweep, including a valley of reduced heterozygosity of 83.4 kb, a skew in the frequency spectrum, and significant linkage disequilibrium on one side of the valley. This region, however, was interrupted by gene conversion events leading to a strong haplotype structure in the center of the valley of reduced variation.

Key Words: Drosophila melanogaster • nucleotide diversity • gene conversion • selective sweep


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This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
D. J. Orengo and M. Aguade
Genome Scans of Variation and Adaptive Change: Extended Analysis of a Candidate Locus Close to the phantom Gene Region in Drosophila melanogaster
Mol. Biol. Evol., May 1, 2007; 24(5): 1122 - 1129.
[Abstract] [Full Text] [PDF]


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