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MBE Advance Access originally published online on September 8, 2005
Molecular Biology and Evolution 2006 23(1):86-92; doi:10.1093/molbev/msj010
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© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Research Article

Evolutionary History of the Coccolithoviridae

Michael J. Allen*, Declan C. Schroeder{dagger}, Matthew T. G. Holden{ddagger} and William H. Wilson*

* Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth, United Kingdom; {dagger} Marine Biological Association, Citadel Hill, Plymouth, United Kingdom; and {ddagger} The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

E-mail: whw{at}pml.ac.uk.

We recently determined the genome sequence of the Coccolithoviridae strain Emiliania huxleyi virus 86 (EhV-86), a giant double-stranded DNA (dsDNA) algal virus from the family Phycodnaviridae that infects the marine coccolithophorid E. huxleyi. Here, we determine the phylogenetic relationship between EhV-86 and other large dsDNA viruses. Twenty-five core genes common to nuclear-cytoplasmic large dsDNA virus genomes were identified in the EhV-86 genome; sequence from eight of these genes were used to create a phylogenetic tree in which EhV-86 was placed firmly with the two other members of the Phycodnaviridae. We have also identified a 100-kb region of the EhV-86 genome which appears to have transferred into this genome from an unknown source. Furthermore, the presence of six RNA polymerase subunits (unique among the Phycodnaviridae) suggests both a unique evolutionary history and a unique lifestyle for this intriguing virus.

Key Words: Phycodnaviridae • Coccolithoviridae • virus • evolution • NCLDV • Emiliania huxleyi


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