MBE Advance Access originally published online on January 12, 2005
Molecular Biology and Evolution 2005 22(4):925-933; doi:10.1093/molbev/msi084
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Research Article |
Widespread Recombination in Published Animal mtDNA Sequences1
* Department of Biology, University of Crete, Iraklio, Crete, Greece; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory 7925, Cape Town, South Africa; Centre for the Study of Evolution & School of Life Sciences, University of Sussex, Brighton, United Kingdom; and Facultad de Biología, Universidad de Vigo, Vigo, Spain
E-mail: zouros{at}biology.uoc.gr.
Mitochondrial DNA (mtDNA) recombination has been observed in several animal species, but there are doubts as to whether it is common or only occurs under special circumstances. Animal mtDNA sequences retrieved from public databases were unambiguously aligned and rigorously tested for evidence of recombination. At least 30 recombination events were detected among 186 alignments examined. Recombinant sequences were found in invertebrates and vertebrates, including primates. It appears that mtDNA recombination may occur regularly in the animal cell but rarely produces new haplotypes because of homoplasmy. Common animal mtDNA recombination would necessitate a reexamination of phylogenetic and biohistorical inference based on the assumption of clonal mtDNA transmission. Recombination may also have an important role in producing and purging mtDNA mutations and thus in mtDNA-based diseases and senescence.
Key Words: animal mtDNA • recombination
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. J. Heidel and G. Glockner Mitochondrial Genome Evolution in the Social Amoebae Mol. Biol. Evol., July 1, 2008; 25(7): 1440 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Wolff, S. Gandre, A. Kalinin, and N. J. Gemmell Delimiting the Frequency of Paternal Leakage of Mitochondrial DNA in Chinook Salmon Genetics, June 1, 2008; 179(2): 1029 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kurabayashi, M. Sumida, H. Yonekawa, F. Glaw, M. Vences, and M. Hasegawa Phylogeny, Recombination, and Mechanisms of Stepwise Mitochondrial Genome Reorganization in Mantellid Frogs from Madagascar Mol. Biol. Evol., May 1, 2008; 25(5): 874 - 891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tang and B. C. Hyman Mitochondrial Genome Haplotype Hypervariation Within the Isopod Parasitic Nematode Thaumamermis cosgrovei Genetics, June 1, 2007; 176(2): 1139 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. M. Amer and Y. Kumazawa The Mitochondrial Genome of the Lizard Calotes versicolor and a Novel Gene Inversion in South Asian Draconine Agamids Mol. Biol. Evol., June 1, 2007; 24(6): 1330 - 1339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Rubinoff, S. Cameron, and K. Will A Genomic Perspective on the Shortcomings of Mitochondrial DNA for "Barcoding" Identification J. Hered., November 1, 2006; 97(6): 581 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Burzynski, M. Zbawicka, D. O. F. Skibinski, and R. Wenne Doubly Uniparental Inheritance Is Associated With High Polymorphism for Rearranged and Recombinant Control Region Haplotypes in Baltic Mytilus trossulus Genetics, November 1, 2006; 174(3): 1081 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Kosakovsky Pond, D. Posada, M. B. Gravenor, C. H. Woelk, and S. D. W. Frost Automated Phylogenetic Detection of Recombination Using a Genetic Algorithm Mol. Biol. Evol., October 1, 2006; 23(10): 1891 - 1901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.C. Spikings, J. Alderson, and J.C.St. John Transmission of mitochondrial DNA following assisted reproduction and nuclear transfer Hum. Reprod. Update, July 1, 2006; 12(4): 401 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Bruen, H. Philippe, and D. Bryant A Simple and Robust Statistical Test for Detecting the Presence of Recombination Genetics, April 1, 2006; 172(4): 2665 - 2681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Galtier, D. Enard, Y. Radondy, E. Bazin, and K. Belkhir Mutation hot spots in mammalian mitochondrial DNA Genome Res., February 1, 2006; 16(2): 215 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Baldo, S. Bordenstein, J. J. Wernegreen, and J. H. Werren Widespread Recombination Throughout Wolbachia Genomes Mol. Biol. Evol., February 1, 2006; 23(2): 437 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Jaramillo-Correa and J. Bousquet Mitochondrial Genome Recombination in the Zone of Contact Between Two Hybridizing Conifers Genetics, December 1, 2005; 171(4): 1951 - 1962. [Abstract] [Full Text] [PDF]
|
|