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MBE Advance Access originally published online on October 20, 2004
Molecular Biology and Evolution 2005 22(3):426-431; doi:10.1093/molbev/msi025
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Molecular Biology and Evolution vol. 22 no. 3 © Society for Molecular Biology and Evolution 2004; all rights reserved.

Research Article

How Strong Is the Mutagenicity of Recombination in Mammals?

Shiao-Wei Huang*,{dagger}, Robert Friedman*,{ddagger}, Ning Yu*, Alex Yu{dagger} and Wen-Hsiung Li*

* Department of Ecology and Evolution, University of Chicago; {dagger} Institute of Zoology, National Taiwan University, Taipei, Taiwan; and {ddagger} Department of Biological Sciences, University of South Carolina, Columbia

E-mail: whli{at}uchicago.edu.

It is commonly believed that a high recombination rate such as that in a pseudoautosomal region (PAR) greatly increases the mutation rate because a 170-fold increase was estimated for the mouse PAR region. However, sequencing PAR and non-PAR introns of the Fxy gene in four Mus taxa, we found an increase of only twofold to fivefold. Furthermore, analyses of sequence data from human and orangutan PAR and X-linked regions and from autosomal regions showed a weak effect of recombination on mutation rate (a slope of less than 0.2% per cM/Mb), although a much stronger effect on GC content (1% to 2% per cM/Mb). Because typical recombination rates in mammals are much lower than those in PARs, the mutagenicity of recombination is weak or, at best, moderate, although its effect on GC% is much stronger. In addition, contrary to a previous study, we found no Fxy duplicate in Mus spretus.

Key Words: pseudoautosomal region • recombination rate • mutation rate • nucleotide substitution


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