Skip Navigation


MBE Advance Access originally published online on October 6, 2004
Molecular Biology and Evolution 2005 22(3):379-382; doi:10.1093/molbev/msi004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Correction to PDF
Right arrow An erratum has been published
Right arrow All Versions of this Article:
22/3/379    most recent
msi004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Perry, G. H.
Right arrow Articles by Stone, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perry, G. H.
Right arrow Articles by Stone, A. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution vol. 22 no. 3 © Society for Molecular Biology and Evolution 2004; all rights reserved.

Comparative Analyses Reveal a Complex History of Molecular Evolution for Human MYH16

George H. Perry*, Brian C. Verrelli{dagger} and Anne C. Stone*

* Department of Anthropology, and {dagger} Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe

E-mail: acstone{at}asu.edu.

Abstract

We describe the pattern of molecular evolution at a sarcomeric myosin gene, MYH16, using more than 30,000 bp of exon and intron sequence data from the chimpanzee and human genome sequencing projects to evaluate the timing and consequences of a human lineage–specific frameshift deletion. We estimate the age of the deletion at approximately 5.3 MYA. This estimate is consistent with the time of human and chimpanzee divergence and is significantly older than the first appearance of the genus Homo in the fossil record. We also find conflicting estimates of nonsynonymous fixation rates (dN) across different regions of this gene, revealing a complex pattern inconsistent with a simple model of pseudogene evolution for human MYH16.

Key Words: MYH16 • sarcomeric myosin • Pan troglodytes • Macaca mulatta


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
G. H. Perry, R. Y. Tito, and B. C. Verrelli
The Evolutionary History of Human and Chimpanzee Y-Chromosome Gene Loss
Mol. Biol. Evol., March 1, 2007; 24(3): 853 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
A. Varki and T. K. Altheide
Comparing the human and chimpanzee genomes: Searching for needles in a haystack
Genome Res., December 1, 2005; 15(12): 1746 - 1758.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.