Skip Navigation


MBE Advance Access originally published online on June 29, 2005
Molecular Biology and Evolution 2005 22(10):2113-2118; doi:10.1093/molbev/msi206
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
22/10/2113    most recent
msi206v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Yang, J.
Right arrow Articles by Li, W.-H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, J.
Right arrow Articles by Li, W.-H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Research Article

Gene Expression Evolves Faster in Narrowly Than in Broadly Expressed Mammalian Genes

Jing Yang*, Andrew I. Su{dagger} and Wen-Hsiung Li*

* Department of Ecology and Evolution, University of Chicago; and {dagger} Genomics Institute of the Novartis Research Foundation, San Diego

E-mail: whli{at}uchicago.edu.

Despite much recent interest, it remains unclear what determines the rate of evolution of gene expression. To study this issue we develop a new measure, called "Expression Conservation Index" (ECI), to quantify the degree of tissue-expression conservation between two homologous genes. Applying this measure to a large set of gene expression data from human and mouse, we show that tissue expression tends to evolve rapidly for genes that are expressed in only a limited number of tissues, whereas tissue expression can be conserved for a long time for genes expressed in a large number of tissues. Therefore, expression breadth is an important determinant for evolutionary conservation of tissue expression. In addition, we find a rapid decrease in ECI with the synonymous divergence between duplicate genes, suggesting fast divergence in tissue expression between duplicate genes.

Key Words: gene expression evolution • expression conservation • duplicate genes • transcription factors


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
M. Throude, S. Bolot, M. Bosio, C. Pont, X. Sarda, U. M. Quraishi, F. Bourgis, P. Lessard, P. Rogowsky, A. Ghesquiere, et al.
Structure and expression analysis of rice paleo duplications
Nucleic Acids Res., March 1, 2009; 37(4): 1248 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. E. Mank, L. Hultin-Rosenberg, E. Axelsson, and H. Ellegren
Rapid Evolution of Female-Biased, but Not Male-Biased, Genes Expressed in the Avian Brain
Mol. Biol. Evol., December 1, 2007; 24(12): 2698 - 2706.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. E. Vinogradov and O. V. Anatskaya
Organismal complexity, cell differentiation and gene expression: human over mouse
Nucleic Acids Res., October 8, 2007; 35(19): 6350 - 6356.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
E. W. Ganko, B. C. Meyers, and T. J. Vision
Divergence in Expression between Duplicated Genes in Arabidopsis
Mol. Biol. Evol., October 1, 2007; 24(10): 2298 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
H. Liang and W.-H. Li
MicroRNA regulation of human protein protein interaction network
RNA, September 1, 2007; 13(9): 1402 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
C. Jiang, L. Han, B. Su, W.-H. Li, and Z. Zhao
Features and Trend of Loss of Promoter-Associated CpG Islands in the Human and Mouse Genomes
Mol. Biol. Evol., September 1, 2007; 24(9): 1991 - 2000.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Gu and Z. Su
Tissue-driven hypothesis of genomic evolution and sequence-expression correlations
PNAS, February 20, 2007; 104(8): 2779 - 2784.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
B.-Y. Liao and J. Zhang
Low Rates of Expression Profile Divergence in Highly Expressed Genes and Tissue-Specific Genes During Mammalian Evolution
Mol. Biol. Evol., June 1, 2006; 23(6): 1119 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
B.-Y. Liao and J. Zhang
Evolutionary Conservation of Expression Profiles Between Human and Mouse Orthologous Genes
Mol. Biol. Evol., March 1, 2006; 23(3): 530 - 540.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.