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Mol. Biol. Evol. 21(9):1620-1624. 2004
DOI: 10.1093/molbev/msh180
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

TAHRE, a Novel Telomeric Retrotransposon from Drosophila melanogaster, Reveals the Origin of Drosophila Telomeres

José P. Abad*,1, Beatriz de Pablos*,{dagger},1, Kazutoyo Osoegawa{ddagger}, Pieter J. de Jong{ddagger}, Antonia Martín-Gallardo{dagger} and Alfredo Villasante*

* Centro de Biología Molecular Severo Ochoa (CBMSO), CSIC-UAM, Madrid, Spain
{dagger} Servicio Interdepartamental de Investigación (SIdI), UAM, Madrid, Spain
{ddagger} Children's Hospital Oakland Research Institute (CHORI) Oakland, CA, USA.

E-mail: avillasante{at}cbm.uam.es

Abstract

Drosophila telomeres do not have typical telomerase repeats. Instead, two families of non-LTR retrotransposons, HeT-A and TART, maintain telomere length by occasional transposition to the chromosome ends. Despite the work on Drosophila telomeres, its evolutionary origin remains controversial. Herein we describe a novel telomere-specific retroelement that we name TAHRE (Telomere-Associated and HeT-A-Related Element). The structure of the three telomere-specific elements indicates a common ancestor. These results suggest that preexisting transposable elements were recruited to perform the cellular function of telomere maintenance. A recruitment similar to that of a retrotransposal reverse transcriptase has been suggested as the common origin of telomerases.

Key Words: telomeres • telomeric retrotransposons • Drosophila


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