MBE Advance Access originally published online on March 24, 2004
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Mol. Biol. Evol. 21(7):1384-1390. 2004
DOI: 10.1093/molbev/msh132
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038
Research Article |
Patterns of Microsatellite Variability Among X Chromosomes and Autosomes Indicate a High Frequency of Beneficial Mutations in Non-African D. simulans
Institut für Tierzucht und Genetik, Veterinärmedizinische Universität, Vienna, Austria
E-mail: christian.schloetterer{at}vu-wien.ac.at.
Abstract
We analyzed microsatellite variability at 42 X-linked and 39 autosomal loci from African and European populations of Drosophila simulans. The African D. simulans harbored significantly more microsatellite variability than the European flies. In the European population, X-linked polymorphism was more reduced than autosomal variation, whereas there was no significant difference between chromosomes in the African population. Previous studies also observed a similar pattern but failed to distinguish between a demographic event and a selection scenario. We performed extensive computer simulations using a wide range of demographic scenarios to distinguish between the two hypotheses. Approximate summary likelihood estimates differed dramatically among X chromosomes and autosomes. Furthermore, our experimental data showed a surplus of X-linked microsatellites with a significantly reduced variability in non-African D. simulans. We conclude that our data are not compatible with a neutral scenario. Thus, the reduced variability at X-linked loci is most likely caused by selective sweeps associated with the out-of-Africa habitat expansion of D. simulans.
Key Words: selective sweep • microsatellites • out-of-Africa • Drosophila simulans
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