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MBE Advance Access originally published online on March 19, 2004
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Mol. Biol. Evol. 21(7):1278-1282. 2004
DOI: 10.1093/molbev/msh125
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Research Article

Reconciling the Numbers: ESTs Versus Protein-Coding Genes

Anton Nekrutenko

Department of Biochemistry and Molecular Biology, The Huck Institutes for Life Sciences, and The Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park

E-mail: nekrut{at}psu.edu.

Abstract

The number of expressed sequences greatly surpasses the estimated number of protein-coding genes in mammalian genomes. An evolutionary approach reveals that only 9% to 14% of human-expressed and mouse-expressed sequences are able to code for proteins. Clustering of these sequences using cross-species relationships suggests that millions of expressed sequences may correspond to only approximately 20,000 distinct protein-coding transcripts.

Key Words: protein-coding genes • human • mouse • comparative genome analysis • ESTs


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