Skip Navigation


MBE Advance Access originally published online on February 12, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/4/724    most recent
msh066v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mousset, S.
Right arrow Articles by Veuille, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mousset, S.
Right arrow Articles by Veuille, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mol. Biol. Evol. 21(4):724-731. 2004
DOI: 10.1093/molbev/msh066
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

A Test of Neutrality and Constant Population Size Based on the Mismatch Distribution

Sylvain Mousset*, Nicolas Derome{dagger} and Michel Veuille{ddagger}

* Section of Evolutionary Biology, Department of Biology II, University of Munich, Munich, Germany
{dagger} Laboratoire Populations Génétique et Evolution, CNRS, Gif-sur-Yvette, France
{ddagger} Laboratoire d'Ecologie, Ecole Pratique des Hautes Etudes, Université Pierre et Marie Curie, Paris, France

E-mail: mousset{at}zi.biologie.uni-muenchen.de.

Several factors including demographic changes, selection, and recombination are known to affect the distribution of the number of pairwise differences between DNA sequences. The effects of each of these forces have previously been used to estimate population parameter values using various assumptions about other factors. In this article, we use the predictions of the mismatch distribution under a standard neutral equilibrium model to design a coalescent simulation-based test and detect any deviation from this equilibrium. When reliable independent estimates are available for the intragenic recombination rate, this test can be used as a neutrality test or a population expansion test in actual studies, under reasonable assumptions.

Key Words: neutrality test • DNA polymorphism • mismatch distribution • selective sweep • demography


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
N. Derome, E. Baudry, D. Ogereau, M. Veuille, and C. Montchamp-Moreau
Selective Sweeps in a 2-Locus Model for Sex-Ratio Meiotic Drive in Drosophila simulans
Mol. Biol. Evol., February 1, 2008; 25(2): 409 - 416.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
E. Baudry, N. Derome, M. Huet, and M. Veuille
Contrasted Polymorphism Patterns in a Large Sample of Populations From the Evolutionary Genetics Model Drosophila simulans
Genetics, June 1, 2006; 173(2): 759 - 767.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
S. I. Wright and B. S. Gaut
Molecular Population Genetics and the Search for Adaptive Evolution in Plants
Mol. Biol. Evol., March 1, 2005; 22(3): 506 - 519.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.