Skip Navigation


MBE Advance Access originally published online on December 5, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
21/2/332    most recent
msh023v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (27)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cobbe, N.
Right arrow Articles by Heck, M. M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cobbe, N.
Right arrow Articles by Heck, M. M. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mol. Biol. Evol. 21(2):332-347. 2004
DOI: 10.1093/molbev/msh023
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

The Evolution of SMC Proteins: Phylogenetic Analysis and Structural Implications

Neville Cobbe and Margarete M. S. Heck

Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom

E-mail: margarete.heck{at}ed.ac.uk.

The SMC proteins are found in nearly all living organisms examined, where they play crucial roles in mitotic chromosome dynamics, regulation of gene expression, and DNA repair. We have explored the phylogenetic relationships of SMC proteins from prokaryotes and eukaryotes, as well as their relationship to similar ABC ATPases, using maximum-likelihood analyses. We have also investigated the coevolution of different domains of eukaryotic SMC proteins and attempted to account for the evolutionary patterns we have observed in terms of available structural data. Based on our analyses, we propose that each of the six eukaryotic SMC subfamilies originated through a series of ancient gene duplication events, with the condensins evolving more rapidly than the cohesins. In addition, we show that the SMC5 and SMC6 subfamily members have evolved comparatively rapidly and suggest that these proteins may perform redundant functions in higher eukaryotes. Finally, we propose a possible structure for the SMC5/SMC6 heterodimer based on patterns of coevolution.

Key Words: SMC • phylogeny • condensin • cohesin • ABC ATPases • maximum likelihood


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
X. Duan, Y. Yang, Y.-H. Chen, J. Arenz, G. K. Rangi, X. Zhao, and H. Ye
Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6
J. Biol. Chem., March 27, 2009; 284(13): 8507 - 8515.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
C. Guthlein, R. M. Wanner, P. Sander, E. C. Bottger, and B. Springer
A Mycobacterial smc Null Mutant Is Proficient in DNA Repair and Long-Term Survival
J. Bacteriol., January 1, 2008; 190(1): 452 - 456.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
W. She, Q. Wang, E. A. Mordukhova, and V. V. Rybenkov
MukEF Is Required for Stable Association of MukB with the Chromosome
J. Bacteriol., October 1, 2007; 189(19): 7062 - 7068.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. D. Cervantes, R. S. Coyne, X. Xi, and M.-C. Yao
The Condensin Complex Is Essential for Amitotic Segregation of Bulk Chromosomes, but Not Nucleoli, in the Ciliate Tetrahymena thermophila
Mol. Cell. Biol., June 15, 2006; 26(12): 4690 - 4700.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
Q. Wang, E. A. Mordukhova, A. L. Edwards, and V. V. Rybenkov
Chromosome Condensation in the Absence of the Non-SMC Subunits of MukBEF.
J. Bacteriol., June 1, 2006; 188(12): 4431 - 4441.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. Cobbe, E. Savvidou, and M. M. S. Heck
Diverse Mitotic and Interphase Functions of Condensins in Drosophila
Genetics, February 1, 2006; 172(2): 991 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
E. Savvidou, N. Cobbe, S. Steffensen, S. Cotterill, and M. M. S. Heck
Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids
J. Cell Sci., June 1, 2005; 118(11): 2529 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Losada and T. Hirano
Dynamic molecular linkers of the genome: the first decade of SMC proteins
Genes & Dev., June 1, 2005; 19(11): 1269 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Aragon
Sumoylation: A new wrestler in the DNA repair ring
PNAS, March 29, 2005; 102(13): 4661 - 4662.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Sergeant, E. Taylor, J. Palecek, M. Fousteri, E. A. Andrews, S. Sweeney, H. Shinagawa, F. Z. Watts, and A. R. Lehmann
Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex
Mol. Cell. Biol., January 1, 2005; 25(1): 172 - 184.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.