Skip Navigation


MBE Advance Access originally published online on August 29, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
21/1/65    most recent
msg237v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (34)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pogson, G. H.
Right arrow Articles by Mesa, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pogson, G. H.
Right arrow Articles by Mesa, K. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mol. Biol. Evol. 21(1):65-75. 2004
DOI: 10.1093/molbev/msg237
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Positive Darwinian Selection at the Pantophysin (Pan I) Locus in Marine Gadid Fishes

Grant H. Pogson and Kathryn A. Mesa

Department of Ecology and Evolutionary Biology, University of California, Santa Cruz

E-mail: pogson{at}darwin.ucsc.edu.

Maximum-likelihood models of codon substitution were used to test for positive Darwinian selection at the vesicle protein pantophysin in two allelic lineages segregating in the Atlantic cod Gadus morhua and in 18 related species of marine gadid fishes. Positive selection was detected in the two intravesicular loops of the integral membrane protein but not in four membrane-spanning regions or the 3' cytoplasmic tail. The proportion of positively selected sites (24.9%) and the mean nonsynonymous/synonymous rate ratio ({omega} = dN/dS = 5.35) were both greater in the first intravesicular (IV1) domain compared with the second intravesicular (IV2) domain (11.0% positively selected sites with mean {omega} = 3.76). Likelihood ratio tests comparing models that assume identical {omega} ratios along all branches of the phylogeny to those that allow {omega} ratios to vary among lineages were not significant for either the IV1 or IV2 domains, indicating that the selective pressures favoring amino acid replacements have operated consistently in both regions during the diversification of the group. Positive selection was observed in the IV1 domain in both G. morhua allelic lineages, and, although three of the four codons that differ between alleles were targets of positive selection in the broader group, no similar polymorphisms were detected in other taxa. The two G. morhua Pan I alleles appeared to have evolved before the speciation event separating it from its sister taxon, Theragra chalcogramma, and on the basis of a standard mtDNA clock are estimated to be at least 2 Myr old. Although the function of pantophysin remains unknown, the strong signal of positive selection at specific sites in the IV1 and IV2 domains may help clarify its role in cellular trafficking pathways.

Key Words: balancing selection • gadid fishes • maximum likelihood • pantophysin • positive selection • S2 ribosomal protein


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
S. M. Carr and H. D. Marshall
Intraspecific Phylogeographic Genomics From Multiple Complete mtDNA Genomes in Atlantic Cod (Gadus morhua): Origins of the "Codmother," Transatlantic Vicariance and Midglacial Population Expansion
Genetics, September 1, 2008; 180(1): 381 - 389.
[Abstract] [Full Text] [PDF]

Home page
 Proc R Soc BHome page
G. R Bigg, C. W Cunningham, G. Ottersen, G. H Pogson, M. R Wadley, and P. Williamson
Ice-age survival of Atlantic cod: agreement between palaeoecology models and genetics
Proc R Soc B, January 22, 2008; 275(1631): 163 - 173.
[Abstract] [Full Text] [PDF]

Home page
 ICES J. Mar. Sci.Home page
C. Pampoulie, P. Steingrund, M. O. Stefansson, and A. K. Danielsdottir
Genetic divergence among East Icelandic and Faroese populations of Atlantic cod provides evidence for historical imprints at neutral and non-neutral markers
ICES J. Mar. Sci., January 1, 2008; 65(1): 65 - 71.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. R. Pie
The Influence of Phylogenetic Uncertainty on the Detection of Positive Darwinian Selection
Mol. Biol. Evol., December 1, 2006; 23(12): 2274 - 2278.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
W. S. Grant, I. B. Spies, and M. F. Canino
Biogeographic Evidence for Selection on Mitochondrial DNA in North Pacific Walleye Pollock Theragra chalcogramma
J. Hered., November 1, 2006; 97(6): 571 - 580.
[Abstract] [Full Text] [PDF]

Home page
 ICES J. Mar. Sci.Home page
D. Bekkevold, M. M. Hansen, and E. E. Nielsen
Genetic impact of gadoid culture on wild fish populations: predictions, lessons from salmonids, and possibilities for minimizing adverse effects
ICES J. Mar. Sci., January 1, 2006; 63(2): 198 - 208.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.