Skip Navigation


MBE Advance Access originally published online on August 29, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
21/1/29    most recent
msg231v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Zhou, G.
Right arrow Articles by He, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhou, G.
Right arrow Articles by He, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mol. Biol. Evol. 21(1):29-36. 2004
DOI: 10.1093/molbev/msg231
© 2004 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Haplotype Structure and Evidence for Positive Selection at the Human IL13 Locus

Gangqiao Zhou*,{dagger}, Yun Zhai*, Xiaojia Dong{dagger}, Xiumei Zhang*, Fengying He{dagger}, Kaixin Zhou*, Yunping Zhu*, Handong Wei*, Zhijian Yao{dagger}, Shaofei Zhong*, Yan Shen{dagger}, Boqing Qiang{dagger} and Fuchu He*,{dagger}

* Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine
{dagger} Chinese National Human Genome Center at Beijing, Beijing, China

E-mail: hefc{at}nic.bmi.ac.cn.

Interleukin-13 (IL13) is believed to play an important role in the pathogenesis of atopy and allergic asthma. To better understand genetic variation at the IL13 locus, we resequenced a 5.1-kb genomic region spanning the entire locus and identified 26 single-nucleotide polymorphisms (SNPs) in 74 individuals from three major populations—Chinese, Caucasian, and African. Our survey suggests exceptionally high and significant geographic structure at the IL13 locus between African and outside Africa populations. This unusual pattern suggests that positive selection that acts in some local populations may have played a role on the IL13 locus. In support of this suggestion, we found a significant excess of high frequency–derived SNPs in the Chinese population and Caucasian population, respectively, as expected after a recent episode of positive selection. Further, the unusual haplotype structure indicates that different scenarios of the action of positive selection on the IL13 locus in different populations may exist. In the Caucasian population, the skewed haplotype distribution dominated by one common haplotype supports the hypothesis of simple directional selection. Whereas, in the Chinese population, the two-round hitchhiking hypothesis may explain the skewed haplotype structure with three dominant ones. These findings may provide insight into the likely relative roles of selection and population history in establishing present-day variation at the IL13 locus, and, motivate further studies of this locus as an important candidate in common diseases association studies.

Key Words: interleukin-13 • single nucleotide polymorphism • positive selection


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
J. M. Akey
Constructing genomic maps of positive selection in humans: Where do we go from here?
Genome Res., May 1, 2009; 19(5): 711 - 722.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Ding and I. J. Kullo
Evolutionary Genetics of Coronary Heart Disease
Circulation, January 27, 2009; 119(3): 459 - 467.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Zhou, Y. Zhai, Y. Cui, X. Zhang, X. Dong, H. Yang, Y. He, K. Yao, H. Zhang, L. Zhi, et al.
MDM2 Promoter SNP309 Is Associated with Risk of Occurrence and Advanced Lymph Node Metastasis of Nasopharyngeal Carcinoma in Chinese Population
Clin. Cancer Res., May 1, 2007; 13(9): 2627 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Cameron, R. B. Webster, J. M. Strempel, P. Kiesler, M. Kabesch, H. Ramachandran, L. Yu, D. A. Stern, P. E. Graves, I. C. Lohman, et al.
Th2 Cell-Selective Enhancement of Human IL13 Transcription by IL13-1112C>T, a Polymorphism Associated with Allergic Inflammation
J. Immunol., December 15, 2006; 177(12): 8633 - 8642.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. N. Le Souef, P. Candelaria, and J. Goldblatt
Evolution and respiratory genetics
Eur. Respir. J., December 1, 2006; 28(6): 1258 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. L. Kelley, J. Madeoy, J. C. Calhoun, W. Swanson, and J. M. Akey
Genomic signatures of positive selection in humans and the limits of outlier approaches
Genome Res., August 1, 2006; 16(8): 980 - 989.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
Y He, G Zhou, Y Zhai, X Dong, L Lv, F He, and K Yao
Association of PLUNC gene polymorphisms with susceptibility to nasopharyngeal carcinoma in a Chinese population
J. Med. Genet., February 1, 2005; 42(2): 172 - 176.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.