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MBE Advance Access originally published online on May 30, 2003
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Mol. Biol. Evol. 20(8):1231-1239. 2003
DOI: 10.1093/molbev/msg147
© 2003 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Estimating the Distribution of Selection Coefficients from Phylogenetic Data with Applications to Mitochondrial and Viral DNA

Rasmus Nielsen*, and Ziheng Yang{dagger}

* Department of Biometrics, Cornell University
{dagger} Department of Biology, University College London, London, England

E-mail: rn28{at}cornell.edu.

The distribution of selection coefficients of new mutations is of key interest in population genetics. In this paper we explore how codon-based likelihood models can be used to estimate the distribution of selection coefficients of new amino acid replacement mutations from phylogenetic data. To obtain such estimates we assume that all mutations at the same site have the same selection coefficient. We first estimate the distribution of selection coefficients from two large viral data sets under the assumption that the viral population size is the same along all lineages of the phylogeny and that the selection coefficients vary among sites. We then implement several new models in which the lineages of the phylogeny may have different population sizes. We apply the new models to a data set consisting of the coding regions from eight primate mitochondrial genomes. The results suggest that there might be little power to determine the exact shape of the distribution of selection coefficient but that the normal and gamma distributions fit the data significantly better than the exponential distribution.

Key Words: dN/dS • maximum likelihood • selection coefficients • neutral theory • mitochondrial DNA • positive selection


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