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MBE Advance Access originally published online on April 2, 2003
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Mol. Biol. Evol. 20(4):660-662. 2003
DOI: 10.1093/molbev/msg066
© 2003 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Directional Evolution of Size Coupled with Ascertainment Bias for Variation in Drosophila Microsatellites

William Amos*, Carolyn M. Hutter{dagger},{ddagger}, Malcolm D. Schug{dagger},§ and Charles F. Aquadro{dagger},

* Department of Zoology, University of Cambridge, Cambridge, England
{dagger} Department of Molecular Biology and Genetics, Cornell University
{ddagger} Department of Epidemiology, University of Washington School of Public Health and Community Medicine
§ Department of Biology, University of North Carolina Greensboro

Species-specific differences in microsatellite locus length and ascertainment bias have both been proposed to explain differences in microsatellite variability and length usually observed when loci isolated in one species are used to survey variation in a related species. Here we provide a simple algebraic approach to independently estimate the contributions of true species-specific length differences and ascertainment bias. We apply this approach to a reciprocal-isolation microsatellite study and show contributions of both ascertainment bias and a true longer average microsatellite length in Drosophila melanogaster compared with D. simulans.

Key Words: Drosophila • microsatellites • ascertainment bias • directional evolution


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