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MBE Advance Access originally published online on August 29, 2003
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Mol. Biol. Evol. 20(12):2104-2112. 2003
DOI: 10.1093/molbev/msg222
© 2003 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Selection on Coding Regions Determined Hox7 Genes Evolution

Mario Ali Fares*,{dagger},1, Daniela Bezemer{dagger}, Andrés Moya*,{dagger} and Ignacio Marín*,

* Departamento de Genética
{dagger} Instituto Cavanilles de Biodiversidad and Biología Evolutiva, Universidad de Valencia, Valencia, Spain

E-mail: ignacio.marin{at}uv.es.

The important role of Hox genes in determining the regionalization of the body plan of the vertebrates makes them invaluable candidates for evolutionary analyses regarding functional and morphological innovation. Gene duplication and gene loss led to a variable number of Hox genes in different vertebrate lineages. The evolutionary forces determining the conservation or loss of Hox genes are poorly understood. In this study, we show that variable selective pressures acted on Hox7 genes in different evolutionary lineages, with episodes of positive selection occurring after gene duplications. Tests for functional divergence in paralogs detected significant differentiation in a region known to modulate HOX7 protein activity. Our results show that both positive and negative selection on coding regions are influencing Hox7 genes evolution.

Key Words: gene duplication • homeotic genes • homeobox • mutual information


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