Skip Navigation


MBE Advance Access originally published online on June 27, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
20/10/1705    most recent
msg193v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Torgerson, D. G.
Right arrow Articles by Singh, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Torgerson, D. G.
Right arrow Articles by Singh, R. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Mol. Biol. Evol. 20(10):1705-1709. 2003
DOI: 10.1093/molbev/msg193
© 2003 by the Society for Molecular Biology and Evolution. ISSN: 0737-4038

Sex-Linked Mammalian Sperm Proteins Evolve Faster Than Autosomal Ones

Dara G. Torgerson and Rama S. Singh

Department of Biology, McMaster University, Hamilton, Ontario, Canada

E-mail: torgerdg{at}mcmaster.ca.

X-linked genes can evolve slower or faster depending on whether most recessive, or at least partially recessive alleles are deleterious or beneficial due to their hemizygous expression in males. Molecular studies of X chromosome divergence have provided conflicting evidence for both a higher and lower rate of nucleotide substitution at both synonymous and nonsynonymous sites, depending on the nucleotide sites sampled. Using human and mouse orthologous genes, we tested the hypothesis that genes encoding male-specific sperm proteins are evolving faster on the X chromosome compared with autosomes. X-linked sperm proteins have an average nonsynonymous mutation rate almost twice as high as sperm genes found on autosomes, unlike other tissue-specific genes, where no significant difference in the nonsynonymous mutation rate between the X chromosome and autosomes was found. However, no difference was found in the average synonymous mutation rate of X-linked versus autosomal sperm proteins, which along with corresponding higher values of Ka/Ks in X-linked sperm proteins suggest that differences in selective forces and not mutation rates are the underlying cause of higher X-linked mammalian sperm protein divergence.

Key Words: Faster X evolution • human-mouse orthologous genes • sperm proteins • selection • X chromosome


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
J. F. Baines, S. A. Sawyer, D. L. Hartl, and J. Parsch
Effects of X-Linkage and Sex-Biased Gene Expression on the Rate of Adaptive Protein Evolution in Drosophila
Mol. Biol. Evol., August 1, 2008; 25(8): 1639 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
C. G. Artieri, W. Haerty, B. P. Gupta, and R. S. Singh
Sexual Selection and Maintenance of Sex: Evidence from Comparisons of Rates of Genomic Accumulation of Mutations and Divergence of Sex-Related Genes in Sexual and Hermaphroditic Species of Caenorhabditis
Mol. Biol. Evol., May 1, 2008; 25(5): 972 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. D. Dean, J. M. Good, and M. W. Nachman
Adaptive Evolution of Proteins Secreted during Sperm Maturation: An Analysis of the Mouse Epididymal Transcriptome
Mol. Biol. Evol., February 1, 2008; 25(2): 383 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
X. Wang and J. Zhang
Rapid evolution of primate ESX1, an X-linked placenta- and testis-expressed homeobox gene
Hum. Mol. Genet., September 1, 2007; 16(17): 2053 - 2060.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. E. Mank, E. Axelsson, and H. Ellegren
Fast-X on the Z: Rapid evolution of sex-linked genes in birds
Genome Res., May 1, 2007; 17(5): 618 - 624.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
C. E. Popescu, T. Borza, J. P. Bielawski, and R. W. Lee
Evolutionary Rates and Expression Level in Chlamydomonas
Genetics, March 1, 2006; 172(3): 1567 - 1576.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. Borge, M. T. Webster, G. Andersson, and G.-P. Saetre
Contrasting Patterns of Polymorphism and Divergence on the Z Chromosome and Autosomes in Two Ficedula Flycatcher Species
Genetics, December 1, 2005; 171(4): 1861 - 1873.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. Nei
Selectionism and Neutralism in Molecular Evolution
Mol. Biol. Evol., December 1, 2005; 22(12): 2318 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. M. Good and M. W. Nachman
Rates of Protein Evolution Are Positively Correlated with Developmental Timing of Expression During Mouse Spermatogenesis
Mol. Biol. Evol., April 1, 2005; 22(4): 1044 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
X. Wang and J. Zhang
Rapid Evolution of Mammalian X-Linked Testis-Expressed Homeobox Genes
Genetics, June 1, 2004; 167(2): 879 - 888.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.