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Molecular Biology and Evolution, Vol 2, 469-477, Copyright © 1985 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Sequence of the ebgA gene of Escherichia coli: comparison with the lacZ gene

HW Stokes, PW Betts and BG Hall
Molecular and Cell Biology Department, University of Connecticut, Storrs 06268.

We have sequenced the ebgA (evolved beta-galactosidase) gene of Escherichia coli K12. The sequence shows 50% nucleotide identity with the E. coli lacZ gene, demonstrating that the two genes are related by descent from a common ancestral gene. Comparison of the two sequences suggests that the ebgA gene has recently been under selection. A significant excess of identical, rather than synonymous, codons used to encode identical amino acids at the same positions in the aligned sequences implies that some form of selection is operating directly at the DNA level. This selection is independent of, and in addition to, selection based on codon usage or on function of the gene products.
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