Molecular Biology and Evolution, Vol 2, 455-468, Copyright © 1985 by Society for Molecular Biology and Evolution
HM Temin
Recent studies indicate that greater than 10% of the human and mouse genome
appears to consist of integrated DNA copies of RNA molecules. These
sequences include retroviruses, retrovirus-like DNAs, retrotransposons, and
retrotranscripts and represent more than 500,000 separate integration
events. The nature of the enzymes used for the reverse transcription from
RNA to DNA and for integration of the DNA copies into chromosomal DNA is
unknown. A major evolutionary effect of these integrations would have been
mutation. Thus, present-day organisms are those that survived this
mutational load.
ORIGINAL ARTICLE
Reverse transcription in the eukaryotic genome: retroviruses, pararetroviruses, retrotransposons, and retrotranscripts
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
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