Molecular Biology and Evolution, Vol 2, 206-216, Copyright © 1985 by Society for Molecular Biology and Evolution
TP Keith, LD Brooks, RC Lewontin, JC Martinez-Cruzado and DL Rigby
In a previous study, Keith (1983) showed by sequential gel electrophoresis
of the esterase-5 protein in Drosophila pseudoobscura that a highly
polymorphic locus with many alleles can have very similar frequency
distributions in populations separated by 500 km. The present work studies
another highly polymorphic locus, xanthine dehydrogenase, in the same
California population samples, using the same technique to distinguish
allelic classes. Twelve electromorphs were found in one population and 15
in the other. Both populations shared a single very frequent (approximately
60%) allele, as well as five other alleles in low but similar frequencies.
In addition, each population had an array of unique alleles present only
once in one population sample but absent in the other. A statistical test
against the stationary distribution for neutral alleles shows that, if the
populations are at equilibrium, then purifying selection is operating on
xanthine dehydrogenase. The extremely close similarity in frequency
distributions of the alleles between populations for both the xanthine
dehydrogenase and esterase-5 loci, despite differences in allele frequency
distribution between loci, strongly emphasizes the importance of migration
in influencing genic diversity in these populations.
ORIGINAL ARTICLE
Nearly identical allelic distributions of xanthine dehydrogenase in two populations of Drosophila pseudoobscura
Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138.
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